HBOT was found to have a role in the initiation and/or facilitation of angiogenesis and cell proliferation processes needed for axonal regeneration. Hyperbaric oxygenation is a potent means of delivering to the brain sufficient oxygen for tissue repair through increased plasma oxygen concentration. More specifically, HBOT induces regeneration of axonal white matter, has positive effect upon the myelinization and maturation of injured neural fibers, and can stimulate axonal growth and increase the ability of neurons to function and communicate with each other.
At the cellular level, HBOT can improve cellular metabolism, reduce apoptosis, alleviate oxidative stress, and increase levels of neurotrophins and nitric oxide through enhancement of mitochondrial function (in both neurons and glial cells). HBOT may promote the neurogenesis of endogenous neural stem cells. With regard to secondary injury mechanisms in mTBI, HBOT can initiate vascular repair mechanism and improve cerebral vascular flow, promote blood brain barrier integrity and reduce inflammatory reactions as well as brain edema.
Hyperbaric oxygen therapy leads to neuroplasticity formation and repairs injured tissue at an accelerated rate | Portland Chiropractic Neurology (portchiro.com)
Hyperbaric oxygen induces late neuroplasticity in post stroke patients--randomized, prospective trial - PubMed (nih.gov)
Impact of Hyperbaric Oxygen Therapy on Cognitive Functions: a Systematic Review | SpringerLink
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